Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

Allergic Reactions

Allergic Reactions

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Microorganisms in Agriculture and Food industry

Microorganisms in Agriculture and Food industry

Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vaccination for Patients With Immunosuppression and Altered Immunity: A Workgroup Report from the AAAAI Adverse Reactions to Drugs, Biologics, and Vaccines Committee and the Autoimmunity and Altered Immune Response Committee.

The journal of allergy and clinical immunology. In practice·2026

Same author

Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.

The lancet. Gastroenterology & hepatology·2026

Same author

Posttraumatic Amnesia and Language Impairments: Reported Diagnostic Practices of Hospital-Based Speech-Language Pathologists.

American journal of speech-language pathology·2026

Same author

A systematic review of ultrasound imaging as a relevant approach for the early detection of pressure injuries in at risk patients.

The British journal of radiology·2026

Same author

Case series: Joubert syndrome and eosinophilic esophagitis.

JPGN reports·2026

Same author

Age-Appropriate Low Dosing for Food Protein-Induced Enterocolitis Syndrome Oral Food Challenges: Proposing a Standardized Approach.

The journal of allergy and clinical immunology. In practice·2026

Same journal

Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.

Clinical reviews in allergy & immunology·2026

Same journal

β-blocker Therapy in Cholinergic Urticaria, Adrenergic Urticaria and the Aquagenic Continuum Beta-Blocker Therapy in Chronic Inducible Urticaria.

Clinical reviews in allergy & immunology·2026

Same journal

Immunopathogenesis and Cytokine Pathways in Reactive Infectious Mucocutaneous Eruption (RIME) in Pediatric Population: Infectious Triggers and Molecular Insights.

Clinical reviews in allergy & immunology·2026

Same journal

Neuropsychological Factors in Vitiligo: Mechanisms and Clinical Application.

Clinical reviews in allergy & immunology·2026

Same journal

Tertiary Lymphoid Structure: A Potential Therapeutic Target Affecting Immune Response in Autoimmune Diseases.

Clinical reviews in allergy & immunology·2026

Same journal

Differentiating Acute-onset Autoimmune Hepatitis From Drug-Induced Autoimmune-like Hepatitis: A Multicenter Study and Score Development.

Clinical reviews in allergy & immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 3, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

IgE-Mediated Food Allergy.

Sara Anvari¹, Jennifer Miller¹, Chih-Yin Yeh¹

¹Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, 1102 Bates Avenue, MC 330.01, Houston, TX, 77030, USA.

Clinical Reviews in Allergy & Immunology

|October 30, 2018

Summary

This summary is machine-generated.

Food allergies involve immune responses to food proteins. Early peanut introduction at 4-6 months is recommended to prevent peanut allergy, with immunotherapy as a future treatment.

Keywords:

Anaphylaxis Food allergy Food allergy diagnosis Food immunotherapy IgE Mast cell Pathophysiology Sensitization Tolerance Treatment of food allergy

More Related Videos

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Related Experiment Videos

Last Updated: Feb 3, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

Immunology
Allergy and Immunology

Background:

Food allergies are adverse immune responses to food proteins, affecting multiple systems.
IgE-mediated food allergies involve rapid symptom onset due to immune cell activation, distinct from delayed non-IgE-mediated reactions.

Purpose of the Study:

To outline the diagnosis and management of IgE-mediated food allergies.
To discuss recent guideline changes regarding early food introduction and future treatment modalities.

Main Methods:

Diagnosis relies on clinical symptoms and evidence of food-specific IgE (skin-prick or serum testing).
Oral food challenges may be used to confirm diagnosis when IgE testing is inconclusive.
Management includes strict avoidance, patient/family education, and prompt treatment of reactions.

Main Results:

Symptom onset likelihood correlates with IgE levels, but severity does not.
Anaphylaxis is the most severe reaction, treated with injectable epinephrine.
Recent guidelines advocate for early peanut introduction (4-6 months) to prevent allergy development.

Conclusions:

Accurate diagnosis of IgE-mediated food allergy is crucial for effective management.
Early introduction of allergenic foods like peanuts shows promise in prevention.
Investigational treatments like immunotherapy offer potential future therapeutic options.