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Updated: Feb 3, 2026
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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
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Multiple functions of HuR in urinary tumors
Fa Zhang1, Zhonglin Cai2, Haidi Lv1
1Department of Urology, Gansu Provincial Hospital, 204 Donggang West Road, Chengguan District, Lanzhou, 730000, Gansu, China.
Journal of Cancer Research and Clinical Oncology
|October 30, 2018
Summary
Human embryonic lethal abnormal visual-like protein (HuR) is crucial in urinary tumors. Targeting HuR shows promise as a therapeutic strategy for these cancers, warranting further clinical trials.
Area of Science:
- Oncology
- Molecular Biology
- RNA Biology
Background:
- Human embryonic lethal abnormal visual-like protein (HuR) is an RNA-binding protein.
- HuR is implicated in the biology of various cancers, including urinary tract tumors.
Purpose of the Study:
- To review current literature on HuR's role in urinary tract tumor biology.
- To explore HuR as a potential therapeutic target in urinary tract cancers.
Main Methods:
- Literature review of studies indexed in PubMed and Medline databases.
Main Results:
- HuR regulates key molecules in urinary tumors via post-transcriptional mechanisms (mRNA trafficking, decay, translation).
- HuR is linked to chemoresistance in urinary tumors.
- HuR may serve as a therapeutic target and a prognostic marker.
Conclusions:
- HuR influences diverse biological characteristics of urinary tumors.
- Targeting HuR presents a promising therapeutic strategy for urinary tract cancers.
- Further preclinical and clinical investigations are needed to validate HuR-targeted therapies.
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