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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

971
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

319
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
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Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
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Potential biomarkers for heart failure.

Che Wang1, Honghui Yang1, Chuanyu Gao1

  • 1Department of Cardiology, Henan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Journal of Cellular Physiology
|October 30, 2018
PubMed
Summary
This summary is machine-generated.

Researchers identified novel biomarkers for heart failure (HF) by analyzing gene expression data. Key genes like ankyrin repeat and SOCS box-containing 14 (ASB14) and cluster of differentiation 163 (CD163) show potential for HF diagnosis and understanding disease progression.

Keywords:
differentially expressed genes (DEGs)function and pathway analysisheart failure (HF)protein-protein interaction (PPI) networktranscription factor (TF) microRNA (miRNA) target gene network

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Area of Science:

  • Biomedical Science
  • Genomics
  • Cardiovascular Research

Background:

  • Heart failure (HF) poses a significant global health challenge.
  • Identifying reliable biomarkers is crucial for early diagnosis and effective management of HF.
  • Existing diagnostic methods may lack the sensitivity and specificity required for optimal patient outcomes.

Purpose of the Study:

  • To identify novel candidate biomarkers for heart failure (HF) using comprehensive bioinformatics analysis.
  • To explore the functional roles and regulatory networks of differentially expressed genes (DEGs) in HF.
  • To validate potential biomarkers through data verification analysis.

Main Methods:

  • Downloaded and analyzed gene expression profile GSE57338 (117 HF, 136 control samples).
  • Employed bioinformatics approaches to identify DEGs and construct protein-protein interaction networks.
  • Investigated transcription factor-microRNA target gene regulatory networks and performed gene-drug association analysis.

Main Results:

  • Identified 376 DEGs, with four key modules in protein-protein interaction networks.
  • Revealed regulatory relationships, such as interferon regulatory factor 1 (IRF1)-C-C motif chemokine ligand 5 (CCL5).
  • Confirmed 118 overlapping DEGs, including ankyrin repeat and SOCS box-containing 14 (ASB14), cluster of differentiation 163 (CD163), and CCL5, as potential HF biomarkers.

Conclusions:

  • ASB14 may contribute to HF progression through protein ubiquitination.
  • CCL5's role in HF may be mediated by the IRF1-CCL5 interaction.
  • Genes such as CD163 are promising biomarkers for heart failure, warranting further investigation.