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Related Concept Videos

Colloids03:22

Colloids

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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RNA Stability01:53

RNA Stability

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Colloids and Suspensions01:17

Colloids and Suspensions

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
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Colloidal precipitates01:09

Colloidal precipitates

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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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What is Genetic Engineering?

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Overview
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Ionic Crystal Structures02:42

Ionic Crystal Structures

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Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
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Fabrication of Inverted Colloidal Crystal Polyethylene glycol Scaffold: A Three-dimensional Cell Culture Platform for Liver Tissue Engineering
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Stabilization of Colloidal Crystals Engineered with DNA.

Taegon Oh1, Sarah S Park2, Chad A Mirkin1,2

  • 1Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, IL, 60208, USA.

Advanced Materials (Deerfield Beach, Fla.)
|October 30, 2018
PubMed
Summary

Scientists developed a new method to stabilize DNA-programmed colloidal crystals using silver ions (Ag+). This creates robust, temperature-stable crystals that can be manipulated in various environments.

Keywords:
colloidal crystalsmetallo-DNAnanoparticle superlatticessilver DNAstability enhancement

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Colloidal crystals programmed with DNA are promising for self-assembly.
  • Conventional DNA-based linkages are sensitive to temperature and environment, limiting applications.

Purpose of the Study:

  • To develop a postsynthetic method for stabilizing DNA-programmed colloidal crystals.
  • To enhance the structural integrity and environmental compatibility of these crystals.

Main Methods:

  • Utilizing silver ions (Ag+) to stabilize DNA duplexes within the crystal lattice.
  • Investigating the effect of Ag+ on interparticle linkages and lattice structure.
  • Reversing the stabilization process via chemical extraction of Ag+.

Main Results:

  • Achieved highly stable colloidal crystals with strong interparticle DNA links.
  • Crystals demonstrated resistance to temperature-induced dissociation and environmental changes (water to organic media/solid state).
  • Observed a reversible ~25% lattice contraction upon Ag+ stabilization.

Conclusions:

  • The Ag+-based postsynthetic method provides a robust way to stabilize DNA-programmed colloidal crystals.
  • This technique enables the study of these materials in diverse, previously incompatible environments.
  • The reversible nature of the stabilization offers tunable control over crystal properties.