Related Experiment Video
Updated: Feb 3, 2026
08:20
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
14.6K
[Current progress in neuroimaging research on treatment resistant depression]
Wei Peng1, Zhiyun Jia2, Qiyong Gong3
1Huaxi Magnetic Resonance Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;Department of Radiology, People's Hospital of Deyang City, Deyang, Sichuan 618000, P.R.China.
Summary
Treatment-resistant depression (TRD) affects 30% of patients, with unclear causes. Neuroimaging reveals abnormalities in the fronto-limbic system, offering new insights into TRD
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Context:
- Depression is a prevalent psychiatric disorder.
- Approximately 30% of patients exhibit treatment-resistant depression (TRD).
- The neurobiological underpinnings of TRD remain largely unknown.
Purpose:
- To review recent advancements in neuroimaging research concerning TRD.
- To provide updated insights into the neurobiology of treatment-resistant depression.
- To highlight imaging evidence relevant to TRD's neurobiological mechanisms.
Summary:
- Neuroimaging techniques non-invasively assess brain structure, function, and metabolism.
- Studies in TRD using neuroimaging have identified significant abnormalities.
- These abnormalities are primarily located within the fronto-limbic system.
Impact:
- Offers novel perspectives on the neurobiology of treatment-resistant depression.
- Provides crucial imaging evidence for future TRD research.
- Contributes to a deeper understanding of psychiatric disorders and treatment resistance.
Related Concept Videos
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
01:05Long-term Depression
33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
01:03Long-term Depression
3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.4K
03:12Freezing Point Depression and Boiling Point Elevation
40.1K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.1K
01:28Depressants
436
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
436
01:18Depression: Overview
883
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
883