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Updated: Feb 3, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
[Current progress in neuroimaging research on treatment resistant depression]
Wei Peng1, Zhiyun Jia2, Qiyong Gong3
1Huaxi Magnetic Resonance Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;Department of Radiology, People's Hospital of Deyang City, Deyang, Sichuan 618000, P.R.China.
Abstract:
Depression is a common psychiatric disorder, and approximately 30% patients with depression do not respond effectively to standard antidepressant medication; this condition is termed treatment resistant depression (TRD) and its neurobiological mechanism remains unclear. Neuroimaging techniques can non-invasively explore changes in brain structure, function and metabolism. These techniques have been applied in neurobiological research of TRD and revealed critical abnormalities in brain structure, function and metabolism in fronto-limbic system. In this paper, we reviewed the latest progress in neuroimaging researches on TRD, providing new insight and imaging evidence for further neurobiological studies of TRD.
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