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[Research progress on the involvement of nuclear receptor in regulating autophagy]

Lingjuan Wu1, Xiaoli Xu1, Jun Lin1

  • 1College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, P.R.China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|October 30, 2018
PubMed

Insights

Nuclear receptors regulate cellular processes and are linked to autophagy, a key metabolic pathway. This review explores how nuclear receptors control autophagy, offering insights into disease treatment strategies.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Context:

  • Nuclear receptors are crucial transcriptional regulators impacting cell growth, metabolism, and disease.
  • Autophagy, a conserved cellular degradation process, is vital for maintaining homeostasis.
  • Dysregulation of autophagy is implicated in various pathological conditions.

Purpose:

  • To review current research on the role of nuclear receptors in autophagy regulation.
  • To elucidate the molecular mechanisms by which specific nuclear receptors influence autophagy.
  • To provide a foundation for developing therapeutic strategies targeting the nuclear receptor-autophagy axis.

Summary:

  • This paper synthesizes findings on the intricate relationship between nuclear receptors and autophagy.
  • It details how distinct nuclear receptors modulate autophagic pathways through various molecular interactions.
  • The review highlights the significance of this interplay in cellular functions and disease pathogenesis.

Impact:

  • Understanding the nuclear receptor-autophagy connection can reveal novel therapeutic targets.
  • This knowledge may lead to innovative treatments for diseases associated with autophagy dysfunction.
  • The findings contribute to a deeper comprehension of fundamental cellular regulatory networks.
Keywords:
autophagyfarnesoid X receptornerve growth factor-induced gene Bnuclear receptorretinoic acid receptorvitamin D receptor

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