Related Experiment Video
Updated: Feb 3, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
Synthesis and Properties of a Highly Congested Tri(9-anthryl)methyl Radical
Tomohiko Nishiuchi1, Seito Aibara1, Takashi Kubo1
1Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.
Abstract:
The synthesis of persistent, neutral organic radicals is challenging because of their inherent reactivities. Herein, we report the synthesis and characterization of a highly congested mesityl-substituted tri(9-anthryl)methyl (TAntM) radical (1). The scaffold was successfully synthesized by circumventing the steric hindrance imposed by the bulky groups surrounding the central methyl carbon atom. The radical has a threefold propeller structure, and the unpaired electron is mainly localized on the central carbon atom. Owing to its congested structure, 1 is remarkably stable, which facilitated handling under ambient conditions. Evaluation of the dynamic behavior of the TAntM scaffold indicated that the stability is due to the bulky anthryl units and the mesityl substituents. Because of its high persistence, wide-range absorption, and good reversible redox properties, 1 has promising applications in organic devices.
Related Concept Videos
Transfer RNA Synthesis
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Radical Reactivity: Nucleophilic Radicals
Radical Reactivity: Electrophilic Radicals
Radicals
Ribosomal RNA Synthesis
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...

