Related Experiment Video

Updated: Feb 3, 2026

Studying Brain Function in Children Using Magnetoencephalography
08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K

High complication rate after extendible endoprosthetic replacement of the proximal tibia: a retrospective study of 42

Panagiotis Tsagozis1,2, Michael Parry1, Robert Grimer1

  • 1a The Royal Orthopaedic Hospital , Bristol Road South , Birmingham , UK.

Acta Orthopaedica
|October 30, 2018
PubMed

Insights

Extendible prostheses for proximal tibia tumor resection in children achieve limb salvage but have high complication rates. Non-invasive lengthening designs offer no benefit and increase infection and amputation risks.

Area of Science:

  • Orthopedic Oncology
  • Pediatric Surgery
  • Biomedical Engineering

Background:

  • Long-term outcomes of extendible prostheses for proximal tibia tumor resection in children remain largely unknown.
  • Reconstruction of the proximal tibia in pediatric oncology patients presents unique challenges for limb preservation.

Purpose of the Study:

  • To investigate the functional outcome, complication rate, and limb salvage rate following extendible prosthesis reconstruction of the proximal tibia in children.
  • To compare the outcomes of conventional versus non-invasive lengthening extendible prostheses.

Main Methods:

  • Retrospective review of 42 children who underwent primary extendible proximal tibia replacement (Stanmore implant) between 1992 and 2013.
  • Analysis of oncological and functional outcomes, complication incidence, and amputation rates.
  • Assessment of Musculoskeletal Tumor Society (MSTS) Scores at final follow-up.

Main Results:

  • Overall limb salvage rate was 35/42 (83%); 7 children (17%) required amputation.
  • High overall complication rate (32/42, 76%), with soft tissue problems (15/42), structural failure (12/42), and infection (12/42) being most common.
  • Non-invasive lengthening prostheses showed a higher infection rate (4/6) and inferior limb survival compared to conventional designs (8/36).

Conclusions:

  • Extendible proximal tibia replacements facilitate limb salvage and provide satisfactory functional outcomes in pediatric patients with bone tumors.
  • The high complication rate necessitates careful patient selection and management.
  • Current non-invasive lengthening technology does not offer advantages and is associated with increased risks of infection and amputation.

More Related Videos

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

611
Standardization of Basket Use in Sialendoscopy: A Ten-Year Retrospective Study09:36

Standardization of Basket Use in Sialendoscopy: A Ten-Year Retrospective Study

Published on: June 6, 2025

580

Related Concept Videos

Bones of the Lower Limb: Tibia and Fibula01:10

Bones of the Lower Limb: Tibia and Fibula

The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
9.4K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
821
Reaction Rate02:53

Reaction Rate

The rate of reaction is the change in the amount of a reactant or product per unit time. Reaction rates are therefore determined by measuring the time dependence of some property that can be related to reactant or product amounts. Rates of reactions that consume or produce gaseous substances, for example, are conveniently determined by measuring changes in volume or pressure.
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
63.3K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
861
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K