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Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
Published on: June 23, 2009
No association between G1359A CB1 polymorphisms and pain in young northeastern Mexicans
Ismael A Rodríguez-Rodríguez1, Karla A Fernandez-Quiroga1, Pilar Dc Morales-San Claudio1
1Facultad de Ciencias Químicas, Universidad Autonoma de Nuevo Leon, Pedro de Alba S/N, Ciudad Universitaria, San Nicolás de los Garza, Nuevo Leon, CP 66455, Mexico.
Aim:
Recent studies show an association between the endocannabinoid system and pain. In this study, we analyzed the association between two CNR1 gene polymorphisms and pain perception in a northeast Mexican population.
Methods:
Genotypic and allelic frequencies were obtained for both polymorphisms. Pain threshold, tolerance and perception were measured using the cold pressor task.
Results:
No significant association between the polymorphisms and pain perception was found (p > 0.05).
Conclusion:
Genotypic and allelic frequencies for both polymorphisms were reported for the first time in a Mexican population; however, our results suggest that there is not a significant association between these and pain.
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