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Updated: Feb 3, 2026
15:03
Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
Published on: July 4, 2007
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Complex interactions between malaria and malnutrition: a systematic literature review
BMC Medicine
|October 30, 2018
Summary
Malnutrition and malaria remain significant threats to children. Chronic malnutrition is linked to severe malaria, but evidence on acute malnutrition and malaria risk is inconclusive, necessitating further research.
Area of Science:
- Global Health
- Pediatrics
- Infectious Diseases
Background:
- Malaria and malnutrition are leading causes of child mortality in resource-poor settings.
- Understanding their complex interplay is vital for effective intervention strategies.
Purpose of the Study:
- To systematically review the evidence on the interplay between malaria and malnutrition.
- To assess the association between malnutrition and malaria risk and treatment efficacy.
Main Methods:
- Systematic review of articles from PubMed, Global Health, and Cochrane Libraries (1980-2018).
- Methodological quality assessed using Newcastle-Ottawa Scale; risk of bias using GRADE.
- PRISMA guidelines followed for reporting.
Main Results:
- 33 articles analyzed; significant methodological heterogeneity precluded meta-analysis.
- No consistent association between acute malnutrition and malaria risk.
- Chronic malnutrition linked to increased malaria severity (high parasitemia, anemia).
- Limited data on malnutrition's impact on artemisinin combination therapies (ACTs) pharmacokinetics/dynamics.
Conclusions:
- Evidence on malnutrition's effect on malaria risk is inconclusive.
- Individual patient data analysis needed to standardize metrics and understand variability.
- Further research on ACTs in malnourished children is crucial for optimizing treatment.
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