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Updated: Feb 3, 2026

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Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
Published on: June 23, 2009
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CACNG2 polymorphisms associate with chronic pain after mastectomy.
Andrey V Bortsov1, Marshall Devor2, Mari A Kaunisto3
1Department of Anesthesiology, Center for Translational Pain Medicine, Duke University, Durham, NC, United States.
Pain
|October 30, 2018
Summary
A specific CACNG2 gene haplotype is linked to chronic pain after breast cancer surgery. This genetic marker may help predict and manage postmastectomy pain in survivors.
Area of Science:
- Genetics
- Pain Medicine
- Oncology
Background:
- Chronic postmastectomy pain (PMP) significantly impacts breast cancer survivors' quality of life.
- Previous research suggested a link between CACNG2 gene polymorphisms and PMP risk.
Purpose of the Study:
- To independently validate the association between a CACNG2 haplotype and PMP risk.
- To investigate the specificity of this genetic marker for other pain conditions and thermal sensitivity.
Main Methods:
- Meta-analysis of two independent patient cohorts and a previous study cohort.
- Evaluation of the CACNG2 marker's predictive value for pain after inguinal hernia repair.
- Assessment of genetic association with thermal sensitivity in postmastectomy and postherniotomy patients.
Main Results:
- The A-C-C haplotype in the CACNG2 gene was confirmed to be significantly associated with PMP risk.
- The marker did not predict pain after laparoscopic hernia repair.
- No association was found between the marker and experimentally induced thermal sensitivity.
Conclusions:
- The A-C-C haplotype (rs4820242, rs2284015, rs2284017) in CACNG2 is a risk factor for PMP.
- This finding advances understanding of PMP pathophysiology.
- The results support potential for personalized pain management strategies in breast cancer survivors.
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