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Published on: July 29, 2021
Assessment of Dural Ectasia Using Computed Tomodensitometry as a Criterion in Marfan Syndrome
Quentin Chuzel, Sophie Dupuis-Girod1, Matthieu Rousset
1Service de Génétique Clinique, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron.
Objective:
The aim of this study was to reevaluate dural ectasia criteria in Marfan syndrome patients fulfilling the revised Ghent criteria.
Methods:
Lumbar computed tomography scans of 19 Marfan patients and 30 matched control subjects were retrospectively assessed. Dural sac ratio (DSR), nerve root sleeve diameter, pedicle width, and a scalloping or meningocele presence were each assessed by 2 readers blinded from the diagnosis. Mann-Whitney-Wilcoxon tests compared the patient and control groups. Receiver operating characteristic curve analysis and multivariate models determined the optimal cutoff value.
Results:
A DSR value greater than 0.69 at L5 (DSR-L5) such as L4 scalloping of more than 2.65 mm (scall-L4) and 6 or more vertebrae showing a scalloping of more than 3 mm (6-scall) were found very specific but with limited sensitivity. Multivariate model combining DSR-L5 + scall-L4 showed good positive predictive value, whereas model combining DSR-L5 + 6-scall showed good negative predictive value.
Conclusions:
Assessment of DSR and vertebral scalloping allows valuable depiction of dural ectasia in Marfan syndrome patients.
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