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piRBase: a comprehensive database of piRNA sequences.

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The piRBase database now offers comprehensive annotations for over 173 million PIWI-interacting RNAs (piRNAs) across 21 species, aiding research into their regulatory roles.

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Area of Science:

  • RNA biology
  • Genomics
  • Bioinformatics

Background:

  • PIWI-interacting RNAs (piRNAs) are crucial small RNAs abundant in the animal germline.
  • Research is actively exploring piRNA functions in epigenetic and post-transcriptional gene regulation, particularly concerning transposons.

Purpose of the Study:

  • To develop and maintain piRBase, a centralized database for collecting and annotating piRNA data.
  • To support functional studies of piRNAs by providing comprehensive, accessible information.

Main Methods:

  • Data integration from 264 datasets across 21 organisms.
  • Development of piRBase database (launched 2014, latest release v2.0 in 2018).
  • Comprehensive annotation of piRNA sequences, targets, and disease associations.

Main Results:

  • piRBase currently houses over 173 million piRNAs.
  • Release v2.0 enhanced annotation of piRNA sequences and included potential target and disease-related piRNA information.
  • All data is freely accessible for browsing, searching, and bulk downloads.

Conclusions:

  • piRBase serves as a valuable resource for the scientific community studying piRNA functions.
  • The database facilitates research in epigenetics, gene regulation, and disease by consolidating extensive piRNA data.