LNCipedia 5: towards a reference set of human long non-coding RNAs

Area of Science:

• Genomics
• Molecular Biology
• Bioinformatics

Background:

• Long non-coding RNA (lncRNA) research has transitioned from gene discovery to functional annotation.
• Thousands of annual publications present a challenge in tracking functionally described lncRNAs.
• Inconsistent lncRNA nomenclature and scattered annotations across resources complicate data integration.

Purpose of the Study:

• To present the fifth release of the human lncRNA database, LNCipedia.
• To provide a curated and high-quality reference set of lncRNAs for the research community.
• To address the challenge of tracking functional lncRNA annotations.

Main Methods:

• Manual literature curation of 2482 lncRNA-related articles.
• Integration of official gene symbols where available.
• Implementation of an improved filtering pipeline for lncRNA gene set generation.

Main Results:

• The fifth release of LNCipedia offers an enhanced, higher-quality reference lncRNA gene set.
• Manual curation and use of official gene symbols improve annotation accuracy.
• The database facilitates better tracking of functionally described lncRNAs.

Conclusions:

• LNCipedia v5 provides a valuable, curated resource for lncRNA research.
• Standardized annotation and improved data quality aid functional studies.
• This database supports the advancement of understanding lncRNA functions.