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Sharp-wave ripple features in macaques depend on behavioral state and cell-type specific firing
Ahmed T Hussin1, Timothy K Leonard2, Kari L Hoffman2,3
1Department of Biology, Centre for Vision Research, York University, Toronto, Ontario, Canada.
Hippocampus
|October 30, 2018
Summary
Sharp-wave ripples (SWRs) during quiescence show larger amplitudes and postripple waves (PRWs) than during tasks. Ripple amplitude during successful memory recall is higher, suggesting SWR features reveal cognitive states.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Systems Neuroscience
Background:
- Sharp-wave ripples (SWRs) are key hippocampal events linked to memory consolidation and retrieval.
- SWRs occur during sleep, immobility, and active exploration in primates.
- Spatiotemporal SWR features and their modulation by cognitive states are poorly understood.
Purpose of the Study:
- Investigate spatiotemporal SWR features during quiescence and active memory-guided visual search in macaques.
- Determine how SWR characteristics differ between quiescent and active states.
- Examine the influence of neural spiking activity and cell types on SWR features.
Main Methods:
- Recorded hippocampal local-field potentials and single-unit activity in macaques.
- Analyzed SWRs during periods of quiescence and a memory-guided visual search task.
- Correlated SWR features (amplitude, duration, PRW) with neural firing patterns and trial outcomes (remembered vs. forgotten).
Main Results:
- SWRs during quiescence exhibited greater amplitudes and larger postripple waves (PRWs) compared to task epochs.
- Ripples during successfully remembered trials had larger amplitudes than those during forgotten trials.
- Spiking activity from specific cell types (pyramidal, basket interneurons) modulated SWR amplitude and PRW magnitude.
Conclusions:
- SWR spatiotemporal features, beyond mere occurrence rates, provide valuable insights into hippocampal network dynamics.
- Changes in SWR features reflect distinct cognitive and vigilance states, including memory performance.
- Neural spiking activity selectively shapes SWR characteristics, highlighting cell-type-specific contributions to these events.
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