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Direct Drug Delivery to Kidney via the Renal Artery
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Novel Agents and Drug Development Needs in Advanced Clear Cell Renal Cancer

Thomas Powles1, Brian Rini1

  • 1Thomas Powles, Royal Free Hospital, and Queen Mary University of London, London, United Kingdom; and Brian Rini, Lerner College of Medicine, and Cleveland Clinic, Cleveland, OH.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|October 30, 2018
PubMed

Insights

The treatment of metastatic clear cell renal cancer is shifting towards immune checkpoint inhibitors and new combinations. Emerging targets like indoleamine 2,3-dioxygenase show promise for future therapies.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Metastatic clear cell renal cancer treatment is evolving rapidly.
  • The paradigm is shifting from vascular endothelial growth factor-targeted therapies to immune checkpoint inhibitors.
  • Novel combinations are becoming the standard of care.

Purpose of the Study:

  • To review novel treatments for metastatic renal cell carcinoma.
  • To discuss promising therapeutic combinations.
  • To consider trial design and clinical application of future therapeutics.

Main Methods:

  • Review of recent clinical data and emerging research.
  • Analysis of immune checkpoint inhibitors and novel targets.
  • Discussion of future therapeutic strategies.

Main Results:

  • Programmed death ligand inhibitors are revolutionizing treatment approaches.
  • New targets such as indoleamine 2,3-dioxygenase, transforming growth factor-β, interleukin-10, and adenosine are under investigation.
  • Novel combinations and future therapeutics show significant potential.

Conclusions:

  • Immune checkpoint inhibitors represent a major advancement in metastatic renal cell carcinoma treatment.
  • Further research into novel targets and combinations is crucial.
  • These advancements will significantly influence future clinical practice.

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