Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.0K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.0K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.9K
Overview
110.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An improved synthesis of the saponin, polyphyllin D.

Carbohydrate research·2001
Same author

A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality.

The Journal of clinical investigation·2001
Same author

Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine.

The New England journal of medicine·2001
Same author

MHC-independent allograft vascular disease: mRNA profile in the MHC congenic rat heterotopic cardiac transplant model.

Transplantation proceedings·2001
Same author

Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells.

American journal of physiology. Renal physiology·2001
Same author

[Morphological studies of myocardial fibrosis in different types of Keshan disease].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2001
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.3K

Pulp Stem Cell-Mediated Functional Pulp Regeneration.

B Sui1,2, C Chen2, X Kou2,3

  • 11 State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, China.

Journal of Dental Research
|October 30, 2018
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) offer promising pulp regeneration by rebuilding dental pulp tissues and achieving vital neurovascularization. This approach advances regenerative endodontics for future dental treatments.

Keywords:
angiogenesisdental pulpendodonticsmesenchymal stromal cellsneurogenesisregenerative medicine

More Related Videos

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
07:32

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages

Published on: September 25, 2021

3.6K
Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions
09:30

Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions

Published on: January 7, 2019

10.8K

Related Experiment Videos

Last Updated: Feb 3, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.3K
In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
07:32

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages

Published on: September 25, 2021

3.6K
Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions
09:30

Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions

Published on: January 7, 2019

10.8K

Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Dental Research

Background:

  • Preserving vital dental pulp with vasculature and nerves is a major dental challenge.
  • Mesenchymal stem cell (MSC) transplantation shows promise for pulp regeneration due to neurovascularization potential.
  • Pulp MSCs from various dental sources possess unique neural crest/glial cell properties and reside in a neurovascular niche.

Purpose of the Study:

  • To review recent advancements in pulp stem cell-mediated pulp regeneration.
  • To highlight the critical role of neurovascularization in successful pulp regeneration.
  • To emphasize the potential of these approaches in regenerative endodontics.

Main Methods:

  • Review of current literature on pulp stem cell-mediated regeneration.
  • Analysis of studies focusing on neurogenesis and angiogenesis in pulp regeneration.
  • Evaluation of clinical outcomes emphasizing in situ neurovascularization.

Main Results:

  • Pulp stem cell-mediated approaches can rebuild complex dental pulp structures in situ.
  • Successful regeneration of vitalized pulp via stem cell transplantation with in situ neurovascularization has been demonstrated.
  • These methods show potential for de novo regeneration of complete dental pulp tissues.

Conclusions:

  • Pulp stem cell transplantation is a key strategy for achieving functional pulp regeneration.
  • Neurovascularization is a crucial outcome in vital pulp regeneration.
  • This regenerative approach represents a promising future direction for endodontics.