Related Experiment Video
Updated: Feb 3, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography
Rachel Patel1,2, Jie Wang1, J Peter Campbell1
1Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
Projection-resolved optical coherence tomographic angiography (PR-OCTA) offers superior imaging of choroidal neovascularization (CNV) by reducing artifacts and improving repeatability. This advanced technique enhances the classification and quantification of CNV compared to conventional methods.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Choroidal neovascularization (CNV) is a leading cause of vision loss in age-related macular degeneration.
- Conventional optical coherence tomographic angiography (OCTA) with slab subtraction can be limited by projection artifacts and signal attenuation.
- Accurate imaging and quantification of CNV are crucial for diagnosis and treatment monitoring.
Purpose of the Study:
- To compare the efficacy of projection-resolved optical coherence tomographic angiography (PR-OCTA) against conventional OCTA with slab subtraction.
- To evaluate PR-OCTA's ability to reduce projection artifacts and signal attenuation in CNV imaging.
- To assess the impact of PR-OCTA on the quantification and classification of CNV.
Main Methods:
- A retrospective cross-sectional study involving 17 eyes with treatment-naïve subfoveal CNV.
- Custom processing of OCTA scans, including slab subtraction and PR-OCTA algorithm application.
- Independent classification of CNV by two masked retina specialists using both conventional OCTA and PR-OCTA.
Main Results:
- PR-OCTA demonstrated significantly greater CNV vessel area (0.67 mm²) and vascular connectivity (96.80%) compared to slab subtraction (0.53 mm², 90.90%).
- PR-OCTA showed superior within-visit repeatability for both vessel area and vascular connectivity.
- Classification agreement with fluorescein angiography/OCT was significantly higher for PR-OCTA (88.2%) than for conventional OCTA (58.8% for one grader).
Conclusions:
- PR-OCTA is a superior technique for imaging CNV, offering enhanced vessel area and connectivity measurements.
- PR-OCTA effectively removes projection artifacts, improving the classification and quantification of CNV components.
- The improved repeatability and accuracy of PR-OCTA facilitate better assessment of CNV in clinical practice.
Related Concept Videos
Fischer Projections
Newman Projections
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
Coordinates and Map Projections
Force Classification
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
Classification of Neurotransmitters
Classification of Leukocytes
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...

