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Ex Vivo Infection of Live Tissue with Oncolytic Viruses
12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

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Oncolytic Viruses for Canine Cancer Treatment

Diana Sánchez1, Gabriela Cesarman-Maus2, Alfredo Amador-Molina3

  • 1Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico. dianasanchezc@hotmail.com.

Cancers
|October 31, 2018
PubMed

Insights

Oncolytic virotherapy shows promise for canine cancer treatment, with viruses like reovirus, myxoma, and vaccinia demonstrating encouraging results in preclinical studies.

Area of Science:

  • Veterinary Oncology
  • Virology
  • Immunotherapy

Background:

  • Oncolytic virotherapy is a promising cancer treatment strategy utilizing viruses for direct tumor cell killing and immune stimulation.
  • Two oncolytic viruses are approved for human cancer treatment, highlighting the therapeutic potential of this approach.

Purpose of the Study:

  • To review in vitro and in vivo studies evaluating oncolytic viruses for cancer treatment in dogs.
  • To identify the most studied oncolytic viruses and tumor types in canine research.

Main Methods:

  • Systematic literature search of PubMed and Google Scholar for published studies on oncolytic viruses in dogs.
  • Inclusion of both natural and genetically modified oncolytic viruses without time restrictions.

Main Results:

  • Reovirus, myxoma virus, and vaccinia virus are the most frequently studied oncolytic viruses in canine cancer.
  • These viruses have shown encouraging results primarily in solid tumors like osteosarcomas, mammary gland tumors, soft tissue sarcomas, and mastocytomas.

Conclusions:

  • Oncolytic virotherapy presents a promising avenue for canine cancer treatment, with several viruses showing potential.
  • Further research is needed to optimize tumor specificity, dosing, antibody management, and safety profiles for successful clinical application in dogs.
Keywords:
canine cancercanine treatmentimmunotherapyoncolytic virus

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