Related Experiment Video
Updated: Feb 3, 2026

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells
Published on: September 8, 2010
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
1Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. rthapar@mdanderson.edu.
Abstract:
DNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to ionizing radiation or replication fork collapse that can lead to genomic instability and cancer. Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs. Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs and RNA-DNA hybrids in the DNA damage response is just beginning to be elucidated. This review summarizes recent discoveries on the identification of non-coding RNAs and RNA-mediated regulation of DSB repair.
More Related Videos
Related Concept Videos
Fixing Double-strand Breaks
Fixing Double-strand Breaks
lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
Overview of DNA Repair
Chemically...
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

