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Clinical Features of and Risk Factors for Hydrocephalus in Childhood Bacterial Meningitis
Liang Huo1, Yuying Fan1, Chunying Jiang1
11 Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Insights
Hydrocephalus is a risk in pediatric bacterial meningitis, especially in infants. Severe symptoms and high protein/CRP levels in cerebrospinal fluid predict its development.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neurology
Background:
- Bacterial meningitis is a serious infection in children.
- Hydrocephalus is a potential complication of bacterial meningitis.
- Understanding risk factors is crucial for early intervention.
Purpose of the Study:
- To identify clinical characteristics of hydrocephalus in children with bacterial meningitis.
- To analyze risk factors associated with hydrocephalus development.
Main Methods:
- Retrospective study conducted from 2010-2016.
- Involved a sample of children diagnosed with bacterial meningitis.
- Data collected from Shengjing Hospital of China Medical University.
Main Results:
- 9.36% of patients developed hydrocephalus.
- Risk factors included rural living, altered consciousness, prior antibiotic use, high CSF protein (>2 g/L), high CRP (>100 mg/L), and dexamethasone use.
- Younger age (<6 months) was common in hydrocephalus cases.
Conclusions:
- Severe clinical presentation at admission is a key predictor.
- Elevated laboratory markers (CSF protein, CRP) are significant indicators.
- Early identification of these factors can guide management.
Objective:
To explore the clinical characteristics of and analyze the risk factors for hydrocephalus in children with bacterial meningitis.
Methods:
Retrospective study of a sample of children with bacterial meningitis seen on the pediatric service of Shengjing Hospital of China Medical University between January 1, 2010, and December 31, 2016.
Results:
Overall, 9.36% (25/267) of patients presented with hydrocephalus. Among patients with hydrocephalus, the age at onset of bacterial meningitis was usually <6 months, 15 patients had confirmed bacterial etiology, and 1 patient died. The most significant results of multivariate analysis for hydrocephalus were a rural living situation, altered level of consciousness, previous treatment with antibiotics, initial cerebrospinal fluid protein >2 g/L, C-reactive protein >100 mg/L, and dexamethasone use.
Conclusions:
A severe clinical manifestation and significant laboratory index at admission are the most important predictors of hydrocephalus in children with bacterial meningitis.
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