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Published on: March 8, 2019
Serum matrix metalloproteinase-9 is a valuable biomarker for identification of abdominal and thoracic aortic
1Department of Cardiovascular Ultrasound, the First Hospital of China Medical University, No.155 Nanjing Bei Street, Heping District, Shenyang, 110001, China.
Background:
Matrix metalloproteinase-9 (MMP9) has been reported to play a key role in the pathogenesis of aortic aneurysm. However, few studies have assessed serum MMP9 levels in both abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA). In this study, we investigated the serum levels of MMP9 in aortic aneurysm to evaluate its predictive and diagnostic efficacy for AAA and TAA, and explored the association of MMP9 with circulating laboratory markers.
Methods:
A total of 296 subjects were enrolled, including 105 AAA patients, 79 TAA patients and 112 healthy controls. The levels of serum MMP9 were detected by enzyme-linked immunosorbent assay (ELISA).
Results:
Compared to control group, both AAA and TAA patients had higher serum MMP9 levels in the overall comparison and subgroup analysis based on subjects aged<65 years, either male or female, hypertension, non-diabetes and non-hyperlipidemia (all P<0.05). Moreover, MMP9 levels were significantly higher in TAA group than those in AAA group in the total comparison, and this discrepancy was also found in the non-diabetes, non-hyperlipidemia and aortic diameter ≥ 5.5 cm subgroup analysis. Serum MMP9 levels were influenced by age and hypertension. There was a positive association of serum MMP9 with CRP (r = 0.33, P < 0.001) and Hcy (r = 0.199, P = 0.033). Multiple logistic analyses showed that serum MMP9 was an independent risk factor for AAA and TAA. Based on receiver operating characteristic (ROC) analysis, the area under the curve (AUC) of MMP9 for predicting TAA was 0.83 with 70% sensitivity and 91% specificity, while the AUC of MMP9 to detect AAA was 0.69 and the sensitivity and specificity were 50% and 88%.
Conclusions:
Serum MMP9 was closely related to the existence of aortic aneurysms and could be a valuable marker for the discrimination of aortic aneurysm, especially for TAA.
Insights
Matrix metalloproteinase-9 (MMP9) is elevated in patients with abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA). Higher MMP9 levels may help diagnose and predict TAA and AAA, especially TAA.
Area of Science:
- Biochemistry
- Cardiovascular Research
- Biomarker Discovery
Background:
- Matrix metalloproteinase-9 (MMP9) is implicated in aortic aneurysm pathogenesis.
- Limited research exists on serum MMP9 levels in both abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA).
Purpose of the Study:
- To investigate serum MMP9 levels in AAA and TAA patients.
- To evaluate the predictive and diagnostic efficacy of MMP9 for AAA and TAA.
- To explore associations between MMP9 and other laboratory markers.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to detect serum MMP9 levels.
- 296 subjects were enrolled: 105 AAA patients, 79 TAA patients, and 112 healthy controls.
Main Results:
- Both AAA and TAA patients exhibited higher serum MMP9 levels compared to controls (P<0.05).
- MMP9 levels were significantly higher in TAA than AAA patients.
- Serum MMP9 is an independent risk factor for AAA and TAA, with strong predictive value for TAA (AUC=0.83).
Conclusions:
- Serum MMP9 is closely associated with the presence of aortic aneurysms.
- MMP9 is a valuable biomarker for discriminating aortic aneurysms, particularly TAA.
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