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The association between Hepcidin and arterial stiffness in a community-dwelling population

Xiaona Wang1, Li Sheng1, Ping Ye2

  • 1Department of Geriatric Cardiology, Chinese PLA General Hospital, Fuxing Road #28, Beijing, 100853, China.

Lipids in Health and Disease
|October 31, 2018
PubMed

Insights

Hepcidin is linked to arterial stiffness, a measure of cardiovascular health. This study found hepcidin levels predict future arterial stiffness, potentially mediated by HDL3-C cholesterol levels.

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Metabolic Research

Background:

  • Hepcidin's association with cardiovascular disease and atherosclerosis is known.
  • The clinical link between hepcidin and arterial stiffness requires further elucidation.

Purpose of the Study:

  • To investigate the association between hepcidin and arterial stiffness.
  • To explore potential mechanisms linking hepcidin and arterial stiffness.

Main Methods:

  • Community-based sample analyzed for plasma hepcidin and arterial stiffness (carotid-femoral pulse wave velocity [PWV]).
  • Longitudinal analysis with a median follow-up of 4.8 years.
  • Multivariable linear regression models used to assess associations.

Main Results:

  • Hepcidin was independently associated with carotid-femoral PWV (P < 0.001).
  • Baseline HDL3-C levels were negatively and independently associated with hepcidin (P = 0.024).
  • HDL2-C showed no significant association with hepcidin at baseline (P = 0.133).

Conclusions:

  • Baseline hepcidin levels predict arterial stiffness independently of traditional vascular risk factors.
  • An association between hepcidin and HDL3-C suggests a role for cholesterol efflux in the hepcidin-arterial stiffness relationship.
Abstract

Keywords:
Carotid–femoral pulse wave velocityHDL3-CHepcidin

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