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Related Concept Videos

What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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Related Experiment Video

Updated: Feb 3, 2026

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning
08:31

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning

Published on: February 5, 2021

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Publisher Correction: Engineered bidirectional promoters enable rapid multi-gene co-expression optimization.

Thomas Vogl1,2, Thomas Kickenweiz1, Julia Pitzer3

  • 1Institute of Molecular Biotechnology, NAWI Graz, Graz University of Technology, Petersgasse 14, 8010, Graz, Austria.

Nature Communications
|October 31, 2018
PubMed
Summary
This summary is machine-generated.

This article has been updated to include the author's ORCID ID and corrected supplementary file descriptions. These administrative changes ensure accurate author attribution and data accessibility for the research.

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Area of Science:

  • Bibliometrics
  • Scholarly Communication

Background:

  • Accurate author identification is crucial in scientific publishing.
  • Proper documentation of supplementary materials enhances research reproducibility.

Purpose of the Study:

  • To update the article record with the author's ORCID ID.
  • To provide corrected descriptions for supplementary files.

Main Methods:

  • Administrative update to the article metadata.
  • Revision of supplementary file documentation.

Main Results:

  • The author Thomas Vogl's ORCID ID has been successfully added.
  • Supplementary file legends are now included for clarity.

Conclusions:

  • These updates improve the discoverability and usability of the published research.
  • Ensuring data integrity and author attribution is a key aspect of scholarly publishing.