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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

1.3K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
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Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Related Experiment Video

Updated: Apr 28, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

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Persistent Fetal Vasculature.

Chonglin Chen1, Hu Xiao1, Xiaoyan Ding1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.)
|October 31, 2018
PubMed
Summary
This summary is machine-generated.

Persistent fetal vasculature (PFV) is a condition where fetal eye blood vessels fail to regress, causing childhood blindness. Early diagnosis and microinvasive surgery offer improved treatment strategies for this vision-threatening disorder.

Keywords:
childpersistent fetal vasculaturevitreous body

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Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Medical Imaging

Background:

  • Fetal vasculature is crucial for developing ocular structures like the lens and retina.
  • Persistent fetal vasculature (PFV) results from the incomplete regression of these embryonic blood vessels.
  • PFV is a significant cause of childhood blindness, accounting for up to 5% in Western countries.

Purpose of the Study:

  • To review the clinical and imaging features of persistent fetal vasculature.
  • To highlight advancements in the treatment of persistent fetal vasculature.
  • To discuss the implications of new surgical techniques for PFV management.

Main Methods:

  • Review of clinical case studies and imaging findings related to PFV.
  • Analysis of current literature on the pathophysiology and treatment of PFV.
  • Synthesis of information on recent surgical interventions and their outcomes.

Main Results:

  • PFV presents with diverse clinical and imaging manifestations.
  • Microinvasive surgical techniques have enhanced the safety and efficacy of early PFV treatment.
  • These advancements pave the way for novel therapeutic strategies.

Conclusions:

  • Understanding PFV's clinical and imaging spectrum is vital for timely diagnosis.
  • Advances in microinvasive surgery represent a significant step forward in managing PFV.
  • Further research into the regulatory mechanisms of fetal vascular regression may yield future treatments.