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Updated: Feb 3, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Long-Term Time-Varying Risk of Readmission After Acute Myocardial Infarction
Umesh N Khot1, Michael J Johnson1, Newton B Wiggins1
11 Department of Cardiology Heart and Vascular Institute Center for Healthcare Delivery Innovation Cleveland OH.
Insights
Readmission after myocardial infarction (MI) peaks early, with cardiovascular causes dominating the first 15 days. A small group of patients accounts for nearly half of all 1-year readmissions, highlighting a need for targeted post-MI care.
Area of Science:
- Cardiology
- Public Health
- Healthcare Quality
Background:
- Readmission after myocardial infarction (MI) is a key quality metric influencing hospital reimbursement.
- Understanding readmission patterns is crucial for improving patient outcomes and healthcare efficiency.
Purpose of the Study:
- To analyze the timing and causes of readmission within one year following myocardial infarction (MI).
- To identify patient subgroups with high readmission rates after MI.
Main Methods:
- Retrospective analysis of 3069 patients discharged after MI between April 2008 and June 2012.
- Readmissions within 12 months were classified by cause: MI-related, other cardiovascular, noncardiovascular, and planned.
- Analysis of readmission rates and timing relative to discharge.
Main Results:
- 21.3% of patients were readmitted at least once, with 4.8% accounting for 43% of total readmissions.
- The highest readmission risk occurred immediately post-discharge, decreasing significantly within 15 days.
- Cardiovascular causes predominated early readmissions, followed by noncardiovascular causes in the middle period.
Conclusions:
- A small proportion of myocardial infarction (MI) patients drive a significant number of 1-year readmissions.
- Readmission risk after MI is highest in the initial post-discharge period, with distinct patterns by cause over time.
- These findings underscore the importance of early and ongoing monitoring for patients post-MI.
Abstract:
Background Readmission after myocardial infarction ( MI ) is a publicly reported quality metric with hospital reimbursement linked to readmission rates. We describe the timing and pattern of readmission by cause within the first year after MI in consecutive patients, regardless of revascularization strategy, payer status, or age. Methods and Results We identified patients discharged after an MI from April 2008 to June 2012. Readmission within 12 months was the primary end point. Readmissions were classified into 4 groups: MI related, other cardiovascular, noncardiovascular, and planned. A total of 3069 patients were discharged after an MI (average age, 65±13 years; and 1941 [63%] men). A total of 655 patients (21.3%) were readmitted at least once (897 total readmissions). A total of 147 patients (4.8%) were readmitted ≥2 times, accounting for 389 readmissions (43%). The instantaneous risk of all-cause readmission was highest (15 readmissions/100 patients per month; 95% confidence interval, 12-19 readmissions/100 patients per month) immediately after discharge, decreased by almost half (8.1 readmissions/100 patients per month; 95% confidence interval, 7.2-9.0 readmissions/100 patients per month) within 15 days, and was substantially lower and relatively constant (1.4 readmissions/100 patients per month; 95% confidence interval, 1.2-1.6 readmissions/100 patients per month) out to 1 year. Cardiovascular causes of readmission were more common early after discharge. Conclusions Most patients with MI are never readmitted, whereas a small minority (≈5%) account for nearly half of 1-year readmissions. The readmission pattern after MI is characterized by an early peak (first 15 days) of cardiovascular readmissions, followed by a middle period (months 1-4) of noncardiovascular readmissions, and ending with a low-risk period (>4 months) during which the risk appears independent of cause.
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