Related Experiment Video
Updated: Feb 3, 2026
06:52
Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
Published on: September 29, 2014
54.6K
Endocan Measurement for Active Behçet Disease.
Ayhan Kul1, Orhan Ateş2, Meltem Alkan Melikoğlu1
1Department of Physical Medicine and Rehabilitation, Medical Faculty of Atatürk University Erzurum, Turkey.
Archives of Rheumatology
|October 31, 2018
Summary
Serum endocan levels correlate with vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) in active Behçet disease. Elevated endocan may serve as a new marker for evaluating Behçet disease prognosis and activity.
Area of Science:
- Immunology
- Rheumatology
- Biochemistry
Background:
- Behçet disease is a chronic inflammatory disorder with complex pathogenesis.
- Biomarkers are needed for monitoring disease activity and prognosis.
Purpose of the Study:
- To investigate the relationship between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) in active Behçet disease patients.
Main Methods:
- A case-control study involving 40 active Behçet disease patients and 40 healthy controls.
- Serum levels of endocan, VEGF, and TNF-α were quantified using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Significantly higher serum levels of endocan, VEGF, and TNF-α were observed in Behçet disease patients compared to controls.
- A strong positive correlation was found between serum endocan and VEGF (r=0.630, p<0.001).
- A strong positive correlation was also found between serum endocan and TNF-α (r=0.713, p<0.001).
Conclusions:
- Serum endocan levels are elevated in active Behçet disease.
- Endocan shows significant positive correlations with VEGF and TNF-α, suggesting a role in the inflammatory process.
- Serum endocan may represent a novel biomarker for assessing Behçet disease activity and predicting outcomes.
Related Concept Videos
01:26Coronary Artery Disease IV: Preventive Measures
693
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
693
01:14Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
231
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
231
01:25Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
224
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
224
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
02:04Co-activators and Co-repressors
8.6K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.6K
02:26tRNA Activation
22.9K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
22.9K