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Updated: Feb 3, 2026
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
De novo convulsive status epilepticus in patients with multiple sclerosis treated with dalfampridine
Emilie Panicucci1, Mikael Cohen1, Veronique Bourg1
1Service de Neurologie, CRCSEP, Hôpital Pasteur 2, Nice, France.
Background:
Dalfampridine extended release (DAL) is a broad-spectrum voltage-gated potassium channel blocker that is indicated in multiple sclerosis to improve the nerve conduction of demyelinated axons. Seizures are a known side effect of DAL, which is contraindicated in patients with a history of epilepsy.
Objective:
Three cases of multiple sclerosis (MS) with de novo convulsive status epilepticus (CSE) probably related to dalfampridine administration are described.
Methods:
No patients had a history of seizures or renal impairment. Biological tests were normal. A brain magnetic resonance imaging (MRI) showed diffuse cortical and subcortical atrophy without active inflammatory lesions.
Results:
All three patients presented with CSE that was attributed to DAL and so was discontinued.
Conclusion:
These case reports illustrate that, aside from seizures, de novo CSE is a potential complication of MS patients treated with DAL.
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