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Published on: April 22, 2019
Determination of reference ranges for coagulation tests in Mexican-mestizo population
Carmina Jiménez-Ramírez, Concepción Rosas-Montañez, Joaquina Romero-Vázquez
1Instituto Mexicano del Seguro Social, Hospital de Traumatología “Victorio de la Fuente Narváez”, Laboratorio de Análisis Clínicos. Ciudad de México, México
Background:
It is necessary to establish biological parameters for each population.
Objective:
To establish reference values for prothrombin time (PT), activated partial thromboplastin time (PTT) and fibrinogen in healthy population and to determine intra- and inter-assay concordance.
Methods:
Cross-sectional study that included 204 women and 202 men from the Blood Donor service. Coagulation tests were carried out in order to obtain reference ranges. All procedures were made according to the Clinical & Laboratory Standards Institute guidelines.
Results:
Mean PT, PTT and fibrinogen were 14.1 s, 28.8 s and 381 mg/dL in men, and 15.1 s, 29.0 s and 381 mg/dL in women. The proposed PT, PTT and fibrinogen reference ranges for men were 12.7 to 16.3 s, 24.2 to 36.3 s and 239 to 276 mg/dL, respectively; for women, 12.7 to 16.6 s, 23.5 to 35.4 s and 276 to 598 mg/dL. The latter was statistically significant (p ≤ 0.001).
Conclusions:
Reference values for blood coagulation tests were determined. This is of great importance for fast medical diagnosis and treatment. The results from this study can be adopted by other clinic laboratories after appropriate validation procedures.
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