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Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy
H Kim Lyerly1,2,3, Takuya Osada4, Zachary C Hartman4,2
1Department of Surgery, Duke University, Durham, North Carolina. lyerl001@mc.duke.edu.
Abstract:
Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal systemic toxicity.See related article by Strauss et al., p. 99.
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