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Is there a relationship between the neutrophil/lymphocyte ratio and bilaterality in patients with coxarthrosis?

Gustavo Göhringer de Almeida Barbosa1, Fabricio Cardozo Vicente1, Miguel Antonio Razia Fagundes1

  • 1Hospital da Beneficência Portuguesa de Porto Alegre, Porto Alegre, RS, Brazil.

Revista Brasileira De Ortopedia
|November 1, 2018
PubMed

Insights

The neutrophil/lymphocyte ratio shows a significant difference in bilateral hip osteoarthritis. This suggests distinct inflammatory dynamics may underlie unilateral versus bilateral coxarthrosis, warranting further investigation.

Area of Science:

  • Rheumatology
  • Immunology
  • Orthopedics

Background:

  • Osteoarthritis (OA) involves complex inflammatory mechanisms.
  • The neutrophil-to-lymphocyte ratio (NLR) is an emerging inflammatory marker.
  • Understanding inflammatory markers in hip OA is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the association between NLR and the presence of hip arthrosis.
  • To explore differences in NLR based on the laterality of hip osteoarthritis (unilateral vs. bilateral).

Main Methods:

  • Retrospective, cross-sectional study analyzing medical records of patients over 18 with hip arthrosis.
  • Statistical analysis using the Mann-Whitney test to compare NLR between groups.
  • Evaluation of both NLR and absolute neutrophil and lymphocyte counts.

Main Results:

  • A statistically significant difference in NLR was observed between patients with bilateral hip arthrosis (p=0.036).
  • No significant differences were found in absolute neutrophil or lymphocyte counts between the groups (p=0.14 and p=0.24, respectively).

Conclusions:

  • The laterality of coxarthrosis (hip osteoarthritis) may be associated with different inflammatory dynamics, as indicated by NLR differences.
  • Further research utilizing flow cytometry is recommended to elucidate the impact of these inflammatory variations.
  • This study highlights potential differences in the inflammatory etiology of unilateral and bilateral hip osteoarthritis.
Abstract

Keywords:
InflammationLymphocytesNeutrophilsOsteoarthrosis

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