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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Related Experiment Video

Updated: Feb 3, 2026

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
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[Research progress on microRNAs involved in vascular development].

Qi Chen1, Qiang-Hua Xu1,2,3,4

  • 1College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|November 1, 2018
PubMed
Summary

MicroRNAs are key regulators in vertebrate vascular development, influencing both endothelial and smooth muscle cells. This review highlights specific microRNAs like miR-126 and miR-143/145 in vascular system formation.

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Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Vascular system development in vertebrates is a complex process.
  • MicroRNAs (miRNAs) are crucial regulators of gene expression at transcriptional and post-transcriptional levels.
  • miRNAs play significant roles in various physiological and pathological processes, including vascular development.

Purpose of the Study:

  • To summarize recent advancements in understanding the role of microRNAs in vertebrate vascular development.
  • To focus on specific microRNAs involved in regulating vascular endothelial cells and vascular smooth muscle cells.

Main Methods:

  • Literature review of recent research on microRNAs in vascular development.
  • Identification and categorization of key microRNAs based on their cellular targets (endothelial vs. smooth muscle cells).

Main Results:

  • MicroRNAs are integral to the regulation of vascular smooth muscle cell and vascular endothelial cell development.
  • Specific microRNAs, including miR-126 and the miR-17/92 family, are highlighted for their roles in endothelial cell regulation.
  • The miR-143/145 family and miR-21 are identified as key regulators in vascular smooth muscle cell development.

Conclusions:

  • MicroRNAs are essential for proper vascular development.
  • Understanding these microRNA pathways offers insights into potential therapeutic targets for vascular diseases.
  • Further research is needed to fully elucidate the multifaceted roles of microRNAs in vascular system formation.