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Updated: Feb 3, 2026

Evaluation of the Spatial Distribution of γH2AX following Ionizing Radiation
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Pathological effects of ionizing radiation: endothelial activation and dysfunction

Bjorn Baselet1,2, Pierre Sonveaux2, Sarah Baatout1,3

  • 1Radiobiology Unit, Belgian Nuclear Research Centre (SCK•CEN), Mol, Belgium.

Cellular and Molecular Life Sciences : CMLS
|November 1, 2018
PubMed

The endothelium, a tissue that forms a single layer of cells lining various organs and cavities of the body, especially the heart and blood as well as lymphatic vessels, plays a complex role in vascular biology. It contributes to key aspects of vascular homeostasis and is also involved in pathophysiological processes, such as thrombosis, inflammation, and hypertension. Epidemiological data show that high doses of ionizing radiation lead to cardiovascular disease over time. The aim of this review is to summarize the current knowledge on endothelial cell activation and dysfunction after ionizing radiation exposure as a central feature preceding the development of cardiovascular diseases.

Keywords:
Endothelial cell retractionMitochondrial dysfunctionPremature senescenceProcoagulationProthrombosisVascular tone

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