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Related Experiment Video

Updated: Feb 3, 2026

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Published on: July 5, 2015

Neuropeptides in sensory signal processing.

Richard Carr¹, Stephan Frings²

¹Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany. richard.carr@medma.uni-heidleberg.de.

Cell and Tissue Research

|November 1, 2018

Summary

This summary is machine-generated.

Sensory neuropeptides like CGRP and SP modulate sensory organ function and afferent signals. This review explores their roles in the sensory periphery, impacting conditions like migraine.

Keywords:

CGRP Chemesthesis Neuropeptide Sensory Trigeminal

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Last Updated: Feb 3, 2026

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Area of Science:

Neuroscience
Molecular Biology
Physiology

Background:

Trigeminal nerve fibers release peptides involved in neuroinflammation and pain processing.
Calcitonin gene-related peptide (CGRP) and substance P (SP) are key sensory neuropeptides with paracrine effects.
CGRP's role in headache and migraine pathogenesis is increasingly recognized.

Purpose of the Study:

To review the evidence for modulatory effects of CGRP and SP in the sensory periphery.
To explore the influence of these neuropeptides on sensory organ function.
To understand their impact on afferent signaling from sensory organs.

Main Methods:

Literature review of existing research on CGRP and SP.
Analysis of studies investigating neuropeptide effects on sensory organs (nose, tongue, eyes, ears).
Synthesis of evidence regarding modulation of afferent signals.

Main Results:

CGRP and SP influence neuroinflammatory and nociceptive processes.
Evidence suggests these neuropeptides modulate sensory organ function.
They impact afferent signals originating from the nose, tongue, eyes, and ears.

Conclusions:

CGRP and SP play significant roles beyond neuroinflammation, extending to sensory periphery modulation.
Further research into these neuropeptides' peripheral actions is warranted.
Understanding these mechanisms may offer new therapeutic targets for sensory disorders.