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E Teston1, V Hingot2, V Faugeras2

  • 1ESPCI Paris, PSL Research University, Inserm U979, CNRS, Institut Langevin, 17 rue Moreau, 75012, Paris, France. eliott.teston@chimie-paris.org.

Biomedical Microdevices
|November 1, 2018
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Summary

Researchers developed a versatile microchip for producing ultrasound-vaporizable microdroplets for targeted drug delivery. This new technology enables the creation of small, biocompatible emulsions essential for preventing microembolism during intravenous injection.

Keywords:
Acoustic droplet vaporizationBiocompatible emulsionsDrug deliveryMicrodroplet generationMicrofluidicsMultiple emulsionsPerfluorocarbons

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Ultrasound-vaporizable microdroplets offer potential for targeted drug delivery.
  • Producing monodisperse, biocompatible microdroplets under 5 μm is crucial for intravenous injection to prevent microembolism.
  • Existing microfluidic techniques have limitations in producing small, multiple emulsions efficiently.

Purpose of the Study:

  • To present a versatile microchip for producing both simple and multiple emulsions.
  • To enable the production of capillary-sized (<5 μm) and biocompatible perfluorocarbon-based emulsions.
  • To advance spatiotemporally-triggered drug delivery applications using ultrasound.

Main Methods:

  • Utilized a parallelized microchannel emulsification system.
  • Engineered a microchip for producing perfluorocarbon in water or water within perfluorocarbon in water emulsions.
  • Employed high-speed camera observations to analyze droplet formation and production regimes.

Main Results:

  • Achieved production of emulsions with diameters <5 μm and a polydispersity index as low as 5%.
  • Demonstrated control over droplet characteristics by manipulating interfacial tension, capillary, and viscosity ratios.
  • Identified key factors influencing droplet formation and different production regimes.

Conclusions:

  • The developed microchip is effective for producing injectable, biocompatible droplets suitable for in vivo applications.
  • This technology facilitates preclinical studies for targeted drug delivery using ultrasound.
  • The findings provide a better understanding of microdroplet formation for advanced therapeutic applications.