Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

95.6K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
95.6K
Peroxisomes01:24

Peroxisomes

21.1K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
21.1K
Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

5.4K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
5.4K
Proteomics01:33

Proteomics

9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.8K
Defining Psychology01:24

Defining Psychology

7.8K
Psychology is the scientific discipline dedicated to understanding both observable behavior and the internal mental processes underlying such behavior. It aims to comprehend human nature and apply this understanding to solve practical problems, enhance well-being, and improve societal outcomes. An example of psychology's application is the study of prosocial behavior, such as why and under what conditions individuals might help strangers in need. This process involves describing observed...
7.8K
Defining Social Psychology01:09

Defining Social Psychology

446
Social psychology investigates how the presence and actions of others influence individual behavior, cognition, and emotion. Examining the social environment's impact provides a scientific framework for understanding how individuals perceive others and are, in turn, influenced by them. This field seeks to uncover the underlying principles guiding social interactions, exploring phenomena such as conformity, obedience, and prosocial behavior.Core Themes in Social PsychologyOne central focus of...
446

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From the FAZ to the TAC: Widespread cytoskeletal engagement of T. brucei KMP11.

Journal of cell scienceĀ·2026
Same author

Mass spectrometry proteomics for studying mitostasis.

Protein science : a publication of the Protein SocietyĀ·2026
Same author

A screening pipeline to characterize stress-induced enzymes uncovers a cellular function for the poorly characterized alcohol dehydrogenase Bdh2.

Journal of cell scienceĀ·2026
Same author

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.

Nature communicationsĀ·2026
Same author

CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCĪ“ phosphorylation.

The EMBO journalĀ·2026
Same author

Evolutionary remodeling of a remnant GET pathway factor into PEX38, an essential peroxin.

Proceedings of the National Academy of Sciences of the United States of AmericaĀ·2026

Related Experiment Video

Updated: Feb 3, 2026

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
11:51

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis

Published on: November 18, 2019

6.3K

Defining the Mammalian Peroxisomal Proteome.

Eden Yifrach1, Sven Fischer2, Silke Oeljeklaus3

  • 1Department of Molecular Genetics, Weizmann Institute of Science, 7610001, Rehovot, Israel.

Sub-Cellular Biochemistry
|November 1, 2018
PubMed
Summary

This study identifies a comprehensive list of mammalian peroxisomal proteins, crucial for understanding metabolic pathways and diagnosing peroxisomal disorders. The curated dataset offers a valuable map of the human peroxisomal proteome.

Keywords:
MammalsMass spectrometryPeroxisomal diseasesPeroxisomeProtein databases

More Related Videos

Skeletal Muscle Gender Dimorphism from Proteomics
09:29

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

13.0K
Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells
09:27

Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells

Published on: June 1, 2018

6.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
11:51

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis

Published on: November 18, 2019

6.3K
Skeletal Muscle Gender Dimorphism from Proteomics
09:29

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

13.0K
Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells
09:27

Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells

Published on: June 1, 2018

6.6K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Peroxisomes have transitioned from being considered cellular oddities to vital organelles hosting key metabolic pathways.
  • These organelles perform over 50 enzymatic functions, utilizing unique or dual-localized proteins.
  • Understanding the peroxisomal proteome is critical for diagnosing peroxisomal disorders and discovering new cellular functions.

Purpose of the Study:

  • To compile a comprehensive list of mammalian peroxisomal and peroxisome-associated proteins.
  • To provide a holistic view of the mammalian peroxisomal proteome.
  • To identify potential novel peroxisomal and peroxisome-associated proteins.

Main Methods:

  • Curated results from multiple quantitative and non-quantitative proteomic studies.
  • Integrated data from UniProtKB and Compartments knowledge channel databases.
  • Analyzed and compiled a comprehensive dataset of peroxisomal proteins.

Main Results:

  • A comprehensive list of mammalian peroxisomal and peroxisome-associated proteins was generated.
  • The analysis provides a holistic overview of the mammalian peroxisomal proteome.
  • Potential new peroxisomal and peroxisome-associated proteins were identified.

Conclusions:

  • The compiled dataset serves as a valuable surrogate map of the human peroxisomal proteome.
  • This resource aids in the diagnosis and treatment of peroxisomal disorders.
  • The findings contribute to uncovering novel peroxisomal functions and regulatory mechanisms.