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Subtyping of IPMN

Toru Furukawa1

  • 1Department of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan. toru.furukawa@med.tohoku.ac.jp.

Methods in Molecular Biology (Clifton, N.J.)
|November 1, 2018
PubMed

Intraductal papillary mucinous neoplasms (IPMNs) characteristically consist of mucin-filled dilated ducts lined with neoplastic cells forming papillae with a diverse range of morphologies and varying grades of atypia. Based on morphological characteristics and immunohistochemical reaction against mucin proteins, IPMNs are classified into four distinct subtypes: gastric, intestinal, pancreatobiliary, and oncocytic. In this chapter, histomorphological criteria and techniques of immunohistochemical staining and its evaluation for subtyping IPMNs are described.

Keywords:
GastricIntestinalMUC1MUC2MUC5ACMUC6OncocyticPancreatobiliary

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