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Related Concept Videos

The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
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Tumor microenvironment: Interactions and therapy.

Masoud Najafi1, Nasser Hashemi Goradel2, Bagher Farhood3

  • 1Department of Radiology and Nuclear Medicine, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Journal of Cellular Physiology
|November 1, 2018
PubMed
Summary
This summary is machine-generated.

The tumor microenvironment (TME) involves complex cell interactions that promote cancer growth. Understanding these signals is crucial for developing advanced cancer immunotherapies targeting the TME.

Keywords:
cancer cellcancer-associated fibroblastcytotoxic T lymphocyteexosomeextracellular matrixhypoxiaimmunosuppressioninteraction (cross-talk)regulatory Ttumor microenvironmenttumor-associated macrophage

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Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • The tumor microenvironment (TME) comprises heterogeneous stromal cells with diverse functions.
  • Interactions between cancer and stromal cells within the TME can promote tumor progression.
  • Sophisticated therapeutic strategies are needed to address these complex tumor-promoting interactions.

Purpose of the Study:

  • To review the architecture and signaling within the TME.
  • To elucidate the cross-communication between cells in the TME.
  • To discuss the targeting of TME components for cancer immunotherapy.

Main Methods:

  • Literature review of TME architecture and signaling pathways.
  • Analysis of intercellular communication mechanisms within the TME.
  • Synthesis of current knowledge on TME-targeted immunotherapies.

Main Results:

  • The TME is a dynamic ecosystem shaped by reciprocal cell signaling.
  • Stromal cells and cancer cells engage in complex paracrine interactions.
  • Targeting TME components offers promising avenues for cancer immunotherapy.

Conclusions:

  • A comprehensive understanding of TME dynamics is essential for effective cancer treatment.
  • Targeting the TME can enhance the efficacy of immunotherapies.
  • Further research into TME-driven signaling is critical for future therapeutic development.