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Updated: Feb 3, 2026
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Denaturing Urea Polyacrylamide Gel Electrophoresis Urea PAGE
Published on: October 29, 2009
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Topical urea in skincare: A review
1Catholic University of Sacred Heart, Rome, Italy.
Dermatologic Therapy
|November 1, 2018
Summary
Urea is a key component of skin
Area of Science:
- Dermatology and skin science.
- Biochemistry of skin barrier function.
Background:
- Skin barrier dysfunction is linked to xerosis, atopic dermatitis, and psoriasis.
- Urea is vital for skin hydration and integrity as part of the natural moisturizing factor.
- Clinical evidence supports urea's role in skin health and disease management.
Purpose of the Study:
- To summarize clinical evidence on urea's effects on skin health.
- To review urea's efficacy in managing skin disorders.
Main Methods:
- Systematic review of clinical studies on topical urea.
- Analysis of urea's effects at different concentrations.
- Evaluation of urea's role in combination therapies.
Main Results:
- Low-dose urea (≤10%) moisturizes skin.
- High-dose urea (>10%) provides keratolytic action.
- Urea enhances penetration of other topical agents.
Conclusions:
- Topical urea is effective for skin moisturization and keratolysis.
- Urea aids in managing various skin conditions.
- Urea's penetration-enhancing properties benefit combination therapies.
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