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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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C1q/TNF-related protein 9: A novel therapeutic target in ischemic stroke?

Cui Yang1,2, Fan Fan1,2, Darrell Sawmiller3

  • 1Department of Clinical Medicine, Chengdu Medical College, Chengdu, China.

Journal of Neuroscience Research
|November 1, 2018
PubMed

Insights

C1q/TNF-related protein 9 (CTRP9) may protect brain tissue and reduce severity in ischemic stroke. This adipokine shows promise as a biomarker and therapeutic target for stroke prevention and treatment.

Area of Science:

  • Cardiovascular Research
  • Neurology
  • Endocrinology

Background:

  • Ischemic stroke is a major public health concern requiring advanced research.
  • C1q/TNF-related protein 9 (CTRP9), an adipokine, is crucial in coronary atherosclerosis disease (CAD) pathogenesis.
  • CAD and ischemic stroke share common vascular disease mechanisms.

Purpose of the Study:

  • To investigate the potential neuroprotective role of CTRP9 in ischemic stroke.
  • To explore CTRP9 as a biomarker and therapeutic target for ischemic stroke.

Main Methods:

  • Review of existing research on CTRP9 in cardiovascular and cerebrovascular diseases.
  • Analysis of shared pathogenetic mechanisms between CAD and ischemic stroke.

Main Results:

  • CTRP9 demonstrates protective functions in CAD, including metabolic regulation, vasodilation, endothelial protection, and plaque stabilization.
  • Shared vascular pathogenesis suggests potential for CTRP9 to impact ischemic stroke.

Conclusions:

  • CTRP9 may protect brain tissue and mitigate lesion severity in ischemic stroke.
  • CTRP9 is proposed as a potential biomarker and therapeutic target for ischemic stroke.

Keywords:
CTRP9adipokinecoronary atherosclerosis diseaseischemic stroke

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