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rhGH Abuse for Sports Performance.

Alan D Rogol1

  • 1Professor, Emeritus, Department of Pediatrics, University of Virginia, Charlottesville, VA, USA,

Pediatric Endocrinology Reviews : PER
|November 1, 2018
PubMed
Summary

Doping has evolved from ancient practices to modern substances like recombinant human growth hormone (rhGH). While rhGH

Area of Science:

  • Sports science
  • Endocrinology
  • Anti-doping research

Background:

  • Athletic doping has a long history, evolving from ancient methods to modern pharmacological agents.
  • Recombinant human growth hormone (rhGH) is a performance-enhancing substance with limited evidence of efficacy.
  • Therapeutic use exemptions and advanced doping control methods are crucial in modern sports.

Purpose of the Study:

  • To review the use of recombinant human growth hormone (rhGH) in athletic doping.
  • To discuss the therapeutic use of rhGH for growth hormone deficiency.
  • To outline current doping control methods, including the athlete's biological passport.

Main Methods:

  • Literature review on rhGH use in sports.
  • Analysis of doping control strategies.
Keywords:
Athlete’s biological passportcarriedDopingDoping controlGrowth hormoneIGF-ISportTherapeutic use exemption

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  • Explanation of the athlete's biological passport concept.

    • Main Results:

    • Evidence for rhGH performance enhancement in athletes is limited.
    • rhGH has established therapeutic applications for growth hormone deficiency.
    • The athlete's biological passport provides a personalized reference range for doping detection.

    Conclusions:

    • The efficacy of rhGH as a doping agent remains unproven.
    • Therapeutic use exemptions are necessary for GH-deficient athletes.
    • The athlete's biological passport is an effective tool for detecting doping via longitudinal monitoring.