Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal abnormalities in nonmodulating essential hypertension.

G H Williams, T J Moore, N K Hollenberg

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term dietary sodium restriction increases adiponectin expression and ameliorates the proinflammatory adipokine profile in obesity.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2014
    Same author

    Predictors of plasma and urinary catecholamine levels in normotensive and hypertensive men and women.

    Journal of human hypertension·2013
    Same author

    Effect of mineralocorticoid receptor antagonist on insulin resistance and endothelial function in obese subjects.

    Diabetes, obesity & metabolism·2013
    Same author

    Nervousness.

    Cleveland Clinic quarterly·2010
    Same author

    Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments.

    British journal of cancer·2010
    Same author

    Psychoses associated with vascular disease.

    Cleveland Clinic quarterly·2010
    Same journal

    Approach to Hyperkalemia: The Role of Diet and Pharmacological Therapies.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    High Protein Diets: What to Tell Our Patients.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Progressive Kidney Dysfunction and Ocular Clues: A Quiz.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    See all related articles

    Essential hypertension patients who are salt-sensitive with normal or high renin levels, termed nonmodulators, show a blood pressure decrease with angiotensin-converting enzyme (ACE) inhibitors. This suggests intrarenal angiotensin II pathway abnormalities in nonmodulators.

    Area of Science:

    • Nephrology
    • Cardiology
    • Hypertension Research

    Background:

    • Hypertension is a complex condition with varying responses to salt intake and medication.
    • Low renin levels in hypertensive patients often correlate with salt and diuretic sensitivity.
    • A subset of hypertensive patients with normal or high renin levels exhibit salt sensitivity and are termed nonmodulators.

    Purpose of the Study:

    • To define the characteristics of nonmodulators, a subset of hypertensive patients.
    • To investigate the pressor response to sodium load in nonmodulators.
    • To explore the effect of angiotensin-converting enzyme (ACE) inhibitors on blood pressure in nonmodulators.

    Main Methods:

    • Classification of hypertensive patients based on renin levels and salt sensitivity.

    Related Experiment Videos

  • Assessment of renal blood flow and aldosterone responsiveness to dietary sodium changes.
  • Administration of short-term angiotensin-converting enzyme (ACE) inhibitors during high sodium load.

    • Main Results:

    • Nonmodulators fail to appropriately modulate renal blood flow and aldosterone in response to sodium changes.
    • Nonmodulators exhibit a pressor response to short-term sodium loads due to impaired sodium excretion.
    • Only nonmodulators demonstrate a decrease in blood pressure when treated with an angiotensin-converting enzyme (ACE) inhibitor on a high sodium diet.

    Conclusions:

    • Nonmodulation in essential hypertension is linked to impaired sodium excretion and potentially abnormal intrarenal angiotensin II regulation.
    • The response to ACE inhibitors in nonmodulators suggests a defect in intrarenal angiotensin II levels or receptor function.
    • Identifying nonmodulators could lead to targeted therapeutic strategies for essential hypertension.