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Total Synthesis of Suillusin
Meng Yao Zhang1, Lara R Malins1, Jas S Ward1
1Research School of Chemistry , Australian National University , Acton , ACT 2601 , Australia.
Abstract:
The first total synthesis of the fungal natural product suillusin is reported. The key features of the synthesis include a Michael-benzoin multicatalytic cascade that assembles the entire carbon framework in a single step, and a Rubottom-Swern oxidation sequence that yields the requisite diketone oxidation state of the core framework. This 10-step synthesis of suillusin will allow further evaluation of the biogenesis and the biological activity of the fungal metabolite.
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