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Updated: Feb 3, 2026

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
Published on: December 25, 2021
Translation, Adaptation and Validation of Rapid Geriatric Assessment to the Brazilian context
F de Souza Orlandi1, R Brochine Lanzotti, J Gomes Duarte
1Fabiana de Souza Orlandi, Rod. Washington Luis, km 235 CEP: 13565-905 São Carlos, São Paulo, Brazil (+55) 16 3306-6673/forlandi@ufscar.br.
Objectives:
Translate, cross-culturally adapt and validate the Rapid Geriatric Assessment (RGA) for Brazilian community-dwelling adults.
Design:
Cross-sectional study, using a quantitative approach.
Setting:
Urban population from the city of São Carlos, located in the interior of São Paulo State, Brazil.
Participants:
148 individuals aged 60 or over.
Measurements:
Participants were assessed using the RGA, Fried Frailty Phenotype, International Physical Activity Questionnaire - long version, Addenbrooke´s Cognitive Exam - Revised Version, Mini Nutritional Assessment, short Form - 36, EuroQol 5-Dimension, Geriatric Depression Scale - short version, in addition to performing Dual Energy X-ray Absorptiometry to diagnose sarcopenia, according to the criteria established by the European Working Group on Sarcopenia in Older People.
Results:
In the translation and adaption process of the RGA, steps recommended by the literature were followed: initial translation, synthesis of translations, backward translation, evaluation from the panel of judges, and pre-test. When evaluating the psychometric properties of the scale, satisfactory reliability (internal consistency and stability) and validity (content, concurrent criterion and convergent, divergent and discriminant construct) were verified.
Conclusion:
The Brazilian version of the RGA is reliable and valid, and can be used in the Brazilian context to evaluate the elderly population.
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Reliability and Validity
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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
Termination of Translation

