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Related Experiment Video

Updated: Feb 3, 2026

Mongolian Gerbils as an Animal Model of Wound Healing

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Published on: January 6, 2023

[A non-healing ulcer between the toes].

Pim A J Keurlings^1,2, J E M Werner³, Judith U Ostertag⁴

¹Radboudumc, afd. Eerstelijnsgeneeskunde, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde

|November 1, 2018

Summary

A non-healing foot ulcer in a 60-year-old man was diagnosed as amelanotic melanoma. Early biopsy is crucial for acral lesions that do not improve with treatment.

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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

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Area of Science:

Dermatology
Oncology
Podiatry

Background:

Acral lesions, particularly on the feet, can present diagnostic challenges.
Amelanotic melanoma, lacking pigment, may mimic benign conditions, delaying diagnosis.

Observation:

A 60-year-old male presented with a persistent, non-healing interdigital ulcer on his right foot.
Initial treatments were ineffective, prompting further investigation.

Findings:

Histopathological examination of a biopsy revealed acrolentiginous amelanotic melanoma.
The patient underwent partial foot amputation, but metastatic disease was detected later.

Implications:

Benign-appearing acral lesions warrant close monitoring if they fail to heal.
Biopsy should be considered for persistent or non-healing acral lesions to rule out malignancy.
Timely diagnosis of amelanotic melanoma is critical for patient outcomes.