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Updated: Feb 3, 2026

Laser Micromachining for Polymer Surface Topography Design
Published on: September 19, 2025
Topography design in model membranes: Where biology meets physics
Sarina Chand1,2, Paul Beales3, Frederik Claeyssens2
11 Centre for Membrane Structure and Dynamics, Krebs Institute and Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK.
Impact Statement:
Artificial membranes with complex topography aid the understanding of biological processes where membrane geometry plays a key regulatory role. In this review, we highlight how emerging material and engineering technologies have been employed to create minimal models of cell signaling pathways, in vitro. These artificial systems allow life scientists to answer ever more challenging questions with regards to mechanisms in cellular biology. In vitro reconstitution of biology is an area that draws on the expertise and collaboration between biophysicists, material scientists and biologists and has recently generated a number of high impact results, some of which are also discussed in this review.
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