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Related Concept Videos

Systematic Sampling Method01:17

Systematic Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
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Systematic Error: Methodological and Sampling Errors01:15

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In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
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The Nucleosome Core Particle02:10

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
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The Nucleosome Core Particle01:12

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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Random and Systematic Errors01:20

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Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
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Sample Preparation for Analysis: Overview01:21

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Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
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Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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How Many Cores Does Systematic Prostate Biopsy Need?: A Large-Sample Retrospective Analysis.

Zhengming Hu1, Jinrui Wang2, Desheng Sun1

  • 1Department of Ultrasonography, Peking University Shenzhen Hospital, Shenzhen, China.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|November 1, 2018
PubMed
Summary

For prostate cancer detection, 10- or 12-core systematic biopsy methods offer higher detection rates. However, a 6-core biopsy is preferred for patients with prostate-specific antigen levels of 20 ng/mL or higher.

Keywords:
biopsyprostatic neoplasmtransrectalultrasound

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Area of Science:

  • Urology
  • Oncology
  • Medical Diagnostics

Background:

  • Systematic prostate biopsy is crucial for diagnosing prostate cancer (PCa).
  • Optimizing the number of biopsy cores is essential for maximizing cancer detection while minimizing patient burden.

Purpose of the Study:

  • To determine the optimal number of cores for individualized systematic prostate biopsy.
  • To compare the detection rates of prostate cancer (PCa) and clinically significant prostate cancer (csPCa) using different systematic biopsy schemes.

Main Methods:

  • Retrospective analysis of clinical data from 1211 patients who underwent 12-core transrectal ultrasound-guided systematic prostate biopsy.
  • Estimation of 6-, 8-, and 10-core biopsy strategies from the performed 12-core biopsies.
  • Comparison of PCa and csPCa detection rates across different core schemes.

Main Results:

  • No significant difference in PCa or csPCa detection between 10- and 12-core methods.
  • In patients with smaller prostates (<15 cm²), the 12-core method showed a significant difference in PCa detection compared to the 6-core method, and differed significantly in csPCa detection from all methods except the 10-core.
  • No significant differences were observed between the 12-core method and other schemes for patients with PSA ≥ 20 ng/mL.
  • The 12-core method differed significantly from other schemes (except 10-core) in patients aged <70 and ≥70 years.

Conclusions:

  • Ten- or 12-core systematic biopsy schemes demonstrate superior detection rates for prostate cancer.
  • For patients with a prostate-specific antigen concentration of 20 ng/mL or higher, a 6-core systematic biopsy is the preferred method.