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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Vascular Calcification Markers and Hemodialysis Vascular Access Complications

Beini Lyu1, Tanushree Banerjee2, Julia J Scialla3

  • 1Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

American Journal of Nephrology
|November 1, 2018
PubMed

Insights

Vascular calcification markers like fetuin-A, osteopontin (OPN), and bone morphogenetic protein-7 (BMP-7) are linked to arteriovenous fistula (AVF) complications in hemodialysis patients. These markers did not show associations with arteriovenous graft (AVG) complications.

Area of Science:

  • Nephrology
  • Vascular Biology
  • Biomarkers

Background:

  • Arteriovenous (AV) access dysfunction is a frequent complication for hemodialysis patients.
  • Vascular calcification markers are linked to cardiovascular outcomes but their role in AV access complications is unclear.

Purpose of the Study:

  • To investigate the association between specific vascular calcification markers and AV access complications in hemodialysis patients.

Main Methods:

  • Measured fetuin-A, osteopontin (OPN), osteoprotegerin (OPG), and bone morphogenetic protein-7 (BMP-7) in 219 hemodialysis patients with permanent AV access.
  • Followed patients for up to 1 year, assessing intervention-free survival for AV fistulas (AVF) and AV grafts (AVG).
  • Analyzed associations using adjusted models for demographic factors, comorbidities, and inflammation.

Main Results:

  • Lower fetuin-A, higher OPN, and higher BMP-7 levels were associated with increased risk of AVF intervention.
  • OPG levels were not significantly associated with AVF intervention risk.
  • No significant associations were found between any studied markers and AVG interventions.

Conclusions:

  • Lower fetuin-A and higher OPN and BMP-7 are linked to AVF complications, suggesting a role in AVF failure.
  • These calcification markers do not appear to be associated with AVG complications.
Abstract

Keywords:
Calcification inhibitorsHemodialysisVascular access complicationsVascular calcification

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