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Updated: Feb 3, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

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Early Left Ventricular Dysfunction Detected by Speckle Tracking in Long-Term Hemodialysis Patients with Valvular

Jiahui Li, Aili Li, Jiali Wang

    Cardiorenal Medicine
    |November 1, 2018
    PubMed

    Insights

    Cardiac valve calcification (VC) in long-term hemodialysis patients is linked to more severe left ventricular hypertrophy (LVH) and impaired heart function. Advanced echocardiography can detect early signs of dysfunction even with normal ejection fraction.

    Area of Science:

    • Cardiology
    • Nephrology
    • Medical Imaging

    Background:

    • Cardiac valve calcification (VC) is prevalent in patients undergoing long-term hemodialysis.
    • The impact of VC on left ventricular (LV) geometry and function, particularly in patients with normal LV ejection fraction (LVEF), remains unclear.

    Purpose of the Study:

    • To investigate the effects of VC on LV geometry and function in long-term hemodialysis patients.
    • To utilize conventional echocardiography and 2D speckle tracking echocardiography (2D-STE) for this assessment.

    Main Methods:

    • 47 long-term hemodialysis patients (≥5 years) were studied.
    • VC was identified via echocardiography.
    • LV longitudinal global strain (GLS) and global circumferential strain were assessed using 2D-STE.

    Main Results:

    • Patients with VC exhibited significantly increased interventricular septum thickness, LV posterior wall thickness, LV mass index, and relative wall thickness, indicating more pronounced LV hypertrophy (LVH).
    • VC patients showed higher mitral annular E/E' values, suggesting increased LV filling pressures and diastolic dysfunction.
    • LV longitudinal systolic function, assessed by GLS, was significantly reduced in patients with VC compared to those without VC.

    Conclusions:

    • Echocardiography-diagnosed cardiac VC in long-term hemodialysis patients correlates with more severe LVH, myocardial damage, and poorer cardiac function.
    • Tissue Doppler imaging and 2D-STE are valuable tools for early detection of subtle cardiac dysfunction in this population, even when LVEF is normal.
    Abstract

    Keywords:
    Cardiac valve calcificationEnd-stage renal diseaseHemodialysisTwo-dimensional strain tracking imaging

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