Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma
Marie-Laure Plissonnier1, Katharina Herzog2,3, Massimo Levrero4,5
1Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), 69003 Lyon, France. marie-laure.plissonnier@inserm.fr.
Viruses
|November 2, 2018
Summary
Hepatitis C virus (HCV) infection can lead to liver cancer. This review explores non-coding RNAs (ncRNAs) as potential biomarkers for early detection of HCV-related hepatocellular carcinoma (HCC).
Area of Science:
- Hepatocellular Carcinoma (HCC) Pathogenesis
- Molecular Oncology
- Viral Hepatitis Research
Background:
- Hepatitis C virus (HCV) infection is a global health concern, significantly contributing to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC).
- Current therapeutic strategies for HCC remain limited, highlighting an urgent need for improved early detection methods.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their roles in gene regulation and cancer development, including HCC.
Purpose of the Study:
- To review recent advancements in understanding ncRNA expression profiles in HCV-related HCC.
- To examine the dysregulation of ncRNAs in the context of HCV-induced carcinogenesis.
- To discuss the clinical potential of ncRNA signatures for the early diagnosis of HCC.
Main Methods:
- Comprehensive literature review of studies on ncRNA expression in HCV-related HCC.
- Analysis of ncRNA dysregulation patterns associated with HCC progression, metastasis, and recurrence.
- Evaluation of current research on ncRNA signatures as diagnostic biomarkers.
Main Results:
- Aberrant ncRNA expression is frequently observed in HCV-related HCC.
- Specific ncRNA profiles correlate with HCC metastasis, invasion, dissemination, and recurrence.
- Emerging evidence supports the utility of ncRNAs as potential biomarkers for early HCC detection.
Conclusions:
- ncRNAs play a critical role in the development and progression of HCV-related HCC.
- ncRNA expression profiling offers a promising avenue for developing novel early detection strategies for HCC.
- Further clinical validation is necessary to translate ncRNA signatures into routine diagnostic tools.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
02:39lncRNA - Long Non-coding RNAs
3.7K
3.7K
02:30siRNA - Small Interfering RNAs
18.6K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.6K
02:57piRNA - Piwi-interacting RNAs
7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
00:50What are Viruses?
128.2K
Overview
128.2K
01:29Nursing Code of Ethics
4.5K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.5K